Drug Information

Drug General Information
Drug ID
D07BIK
Former ID
DIB016422
Drug Name
VEL-0230
Synonyms
NC-2300; Osteoporosis therapy (oral), Velcura/Nippon Chemiphar
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 1 [551545]
Company
Nippon Chemiphar Co Ltd
Formula
C14H24NNaO5
Canonical SMILES
O1[C@@H]([C@H]1C(=O)N[C@@H](CC(C)C)COCC(C)C)C(=O)[O-].[<br />Na+]
CAS Number
CAS 221144-20-3
PubChem Compound ID
25102841
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [526178]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 551545Velcura Therapeutics, Inc. to Begin Clinical Trials in Rheumatoid Arthritis Patients. Velcura Therapeutics, Inc. JANUARY 07, 2009.
Ref 526178Discovery and parallel synthesis of a new class of cathepsin K inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.

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