Drug Information

Drug General Information
Drug ID
D07ADX
Former ID
DIB021139
Drug Name
URMC-099
Synonyms
compound 1 [PMID 24044867]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532479]
Formula
C27H27N5
InChI
InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
InChIKey
QKKIWEILHCXECO-UHFFFAOYSA-N
PubChem Compound ID
54764565
PubChem Substance ID
131528782, 174493954, 175453884, 223366900, 224571608, 227010803, 247213050, 249565786, 249714993, 252237590, 252237612, 252448152, 252543481, 252551997
Target and Pathway
Target(s) leucine-rich repeat kinase 2 Target Info Inhibitor [532479]
cyclin-dependent kinase-like 2 (CDC2-related kinase) Target Info Inhibitor [532479]
Mitogen-activated protein kinase kinase kinase 11 Target Info Inhibitor [532479]
Mitogen-activated protein kinase kinase kinase 2 Target Info Inhibitor [532479]
death-associated protein kinase 3 Target Info Inhibitor [532479]
SRSF protein kinase 2 Target Info Inhibitor [532479]
Mitogen-activated protein kinase kinase kinase 9 Target Info Inhibitor [532479]
Mitogen-activated protein kinase kinase kinase 10 Target Info Inhibitor [532479]
FL cytokine receptor Target Info Inhibitor [532479]
KEGG Pathway MAPK signaling pathway
Non-alcoholic fatty liver disease (NAFLD)hsa04010:MAPK signaling pathway
Gap junction
GnRH signaling pathwayhsa04060:Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway CCKR signaling map STP00010:B cell activation
EGF receptor signaling pathway
FGF signaling pathwayP00029:Huntington disease
p38 MAPK pathway
Pathway Interaction Database Reelin signaling pathway
CDC42 signaling events
IFN-gamma pathway
RAC1 signaling pathwayerbb1_downstream_pathway:ErbB1 downstream signaling
Trk receptor signaling mediated by the MAPK pathwayp38_mkk3_6pathway:p38 MAPK signaling pathway
WikiPathways Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
MAPK Signaling Pathway
BDNF signaling pathway
IL-1 signaling pathwayWP481:Insulin Signaling
p38 MAPK Signaling PathwayWP481:Insulin Signaling
References
Ref 532479Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.
Ref 532479Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.

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