Drug Information

Drug General Information
Drug ID
D06YFT
Former ID
DIB018509
Drug Name
1-methyl-L-tryptophan
Synonyms
1-L-MT; 1-LMT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528360]
Formula
C12H14N2O2
InChI
InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
InChIKey
ZADWXFSZEAPBJS-JTQLQIEISA-N
PubChem Compound ID
676159
PubChem Substance ID
3138569, 9281121, 15068214, 24714968, 24868339, 44861306, 56424231, 57408519, 74441382, 92456839, 93166598, 99373846, 103579834, 104098852, 109857891, 118260437, 124557225, 129873352, 131305213, 134346667, 135055726, 136912400, 139137891, 143394395, 152165747, 152245670, 160824198, 162185385, 162244589, 162501137, 163386621, 172860411, 179325009, 201760157, 202539267, 202540570, 204430147, 223519681, 224515657, 226409605, 249565905, 249855538, 250202628, 252067475, 252134697, 252375444, 252417691
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [532500]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 528360Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. Biotechnol J. 2006 Mar;1(3):282-8.
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.

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