Drug Information

Drug General Information
Drug ID
D06XDS
Former ID
DIB005747
Drug Name
GSK-1070806
Synonyms
Anti-IL-18 monoclonal antibody (intravenous, inflammatory bowel disease), GSK
Drug Type
Antibody
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [523987]
Company
GlaxoSmithKline
Target and Pathway
Target(s) Interleukin-18 Target Info [544164]
KEGG Pathway Cytokine-cytokine receptor interaction
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Salmonella infection
Legionellosis
African trypanosomiasis
Malaria
Tuberculosis
Influenza A
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Toll receptor signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
IL23-mediated signaling events
Cellular roles of Anthrax toxin
IL12 signaling mediated by STAT4
Reactome Interleukin-1 processing
WikiPathways Hypertrophy Model
IL1 and megakaryotyces in obesity
Corticotropin-releasing hormone
NOD pathway
References
Ref 523987ClinicalTrials.gov (NCT01648153) Investigate the Efficacy and Safety of GSK1070806 in Obese Subjects With T2DM. U.S. National Institutes of Health.
Ref 544164Targeting the IL-1 family members in skin inflammation. Curr Opin Investig Drugs. 2010 November; 11(11): 1211-1220.

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