Drug Information

Drug General Information
Drug ID
D06VZS
Former ID
DIB020612
Drug Name
ONO-AE1-329
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539233]
Formula
C23H32O6S2
InChI
InChI=1S/C23H32O6S2/c1-29-14-17-6-3-2-5-16(17)7-8-18(24)9-10-19-20(25)13-21(26)23(19)31-12-4-11-30-15-22(27)28/h2-3,5-6,9-10,18-20,23-25H,4,7-8,11-15H2,1H3,(H,27,28)/b10-9+/t18-,19-,20+,23+/m0/s1
InChIKey
BVGVPUMSPSNRRQ-CNOJNPITSA-N
PubChem Compound ID
5311230
PubChem Substance ID
7979737, 39340938, 53193752, 114155613, 135650768, 239135632
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [525735]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525735]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [525735]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Pathways in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 539233(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1933).
Ref 525735The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9.

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