Drug Information

Drug General Information
Drug ID
D06UKS
Former ID
DIB019244
Drug Name
compound 14k
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531649]
Formula
C20H13ClN6
InChI
InChI=1S/C20H13ClN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
InChIKey
WNOHFJIMKSDPHP-UHFFFAOYSA-N
PubChem Compound ID
44222958
PubChem Substance ID
85237688, 136940440, 136961611, 137867941, 235469737, 245305187, 249565894
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [531649]
Serine/threonine-proteinkinase pim-2 Target Info Inhibitor [531649]
casein kinase 1, gamma 3 Target Info Inhibitor [531649]
Proto-oncogene pim-1 Target Info Inhibitor [531649]
PIM-3 protein kinase Target Info Inhibitor [531649]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa05221:Acute myeloid leukemiahsa04630:Jak-STAT signaling pathway
MicroRNAs in cancer
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling PathwayNetPath_20:IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways Hematopoietic Stem Cell DifferentiationWP2858:Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 5316497-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92.
Ref 5316497-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92.

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