Drug Information

Drug General Information
Drug ID
D06QEN
Former ID
DNC012114
Drug Name
7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534126]
Formula
C11H11N5
Canonical SMILES
CN1C=CC2=C1C=CC3=C2C(=NC(=N3)N)N
InChI
1S/C11H11N5/c1-16-5-4-6-8(16)3-2-7-9(6)10(12)15-11(13)14-7/h2-5H,1H3,(H4,12,13,14,15)
InChIKey
WSISEVQVCUARDZ-UHFFFAOYSA-N
PubChem Compound ID
467889
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [534126]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 534126J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Ref 534126J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

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