Drug Information

Drug General Information
Drug ID
D06HVH
Former ID
DIB019335
Drug Name
compound 20
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531724]
Formula
C17H16Cl2N4O
InChI
InChI=1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24)
InChIKey
OWAWOKKHZNRHGV-UHFFFAOYSA-N
PubChem Compound ID
54613583
PubChem Substance ID
131408431, 135648482, 136349959, 136925460, 136967229, 249565836
Target and Pathway
Target(s) Calmodulin-dependent kinase II Target Info Inhibitor [531724]
PIM-3 protein kinase Target Info Inhibitor [531724]
Proto-oncogene pim-1 Target Info Inhibitor [531724]
protein kinase N1 Target Info Inhibitor [531724]
KEGG Pathway Jak-STAT signaling pathway
MicroRNAs in cancer
Acute myeloid leukemia
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 5317247,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.
Ref 5317247,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.

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