Drug Information

Drug General Information
Drug ID
D06GNE
Former ID
DIB019770
Drug Name
IC86621
Synonyms
IC86621
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541240]
Formula
C12H15NO3
InChI
InChI=1S/C12H15NO3/c1-9(14)11-3-2-10(8-12(11)15)13-4-6-16-7-5-13/h2-3,8,15H,4-7H2,1H3
InChIKey
YHKSBKQXCWHTQL-UHFFFAOYSA-N
PubChem Compound ID
9859309
PubChem Substance ID
14822702, 24152678, 24895962, 26758567, 29217565, 45281604, 53800803, 57373578, 76935239, 85845066, 99302650, 121379634, 137013883, 139537292, 162248649, 162527473, 163315731, 163347060, 163688272, 164213621, 175607399, 178102583, 179042908, 184818063, 188942255, 204375287, 208265013, 208265533, 212559559, 226902925, 249127951, 252483881
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [531979]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 541240(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5960).
Ref 531979Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9.

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