Drug Information

Drug General Information
Drug ID
D06GFV
Former ID
DNC011525
Drug Name
1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533479]
Formula
C12H18N2
Canonical SMILES
CCC(CC1=CC2=C(C=C1)NCC2)N
InChI
1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
InChIKey
WHXRWSJORCUAFO-UHFFFAOYSA-N
PubChem Compound ID
13660291
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [533479]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [533479]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 533479J Med Chem. 1986 Aug;29(8):1406-12.Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.
Ref 533479J Med Chem. 1986 Aug;29(8):1406-12.Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.

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