Drug Information

Drug General Information
Drug ID
D06FIK
Former ID
DIB020108
Drug Name
JNJ-17156516
Synonyms
JNJ 17156516
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543267]
Formula
C26H22Cl2N2O3
InChI
InChI=1S/C26H22Cl2N2O3/c1-16-4-3-5-17(12-16)22(26(31)32)14-19-15-25(18-6-11-23(27)24(28)13-18)30(29-19)20-7-9-21(33-2)10-8-20/h3-13,15,22H,14H2,1-2H3,(H,31,32)/t22-/m0/s1
InChIKey
UZCIUKFEIOCAOC-QFIPXVFZSA-N
PubChem Compound ID
11488979
PubChem Substance ID
16781394, 23622881, 42567856, 78509799, 103555632, 135650445, 139107759, 172113647, 198943360, 223862908, 229974165, 243830031, 248332849
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [528980]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543267(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 877).
Ref 5289803-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: in vitro and in vivo pharmacological comparison with dexloxiglumide. J Pharmacol Exp Ther. 2007 Nov;323(2):562-9. Epub 2007 Aug 7.

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