Drug Information

Drug General Information
Drug ID
D06CCR
Former ID
DIB007530
Drug Name
Fialuridine
Synonyms
FIAU
Drug Type
Small molecular drug
Indication HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1] Phase 2 [521412]
Company
Oclassen Pharmaceuticals Inc
Formula
C9H10FIN2O5
Canonical SMILES
n1([C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)c(=O)[nH]c(=O)c(c<br />1)I
CAS Number
CAS 69123-98-4
PubChem Compound ID
46781574
Target and Pathway
Target(s) DNA polymerase Target Info Modulator [534117]
References
Ref 521412ClinicalTrials.gov (NCT00000654) The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAU. U.S. National Institutes of Health.
Ref 534117Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7.

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