Drug Information

Drug General Information
Drug ID
D05XTO
Former ID
DIB013864
Drug Name
ABT-100
Synonyms
A-367074; A-409100; A-367074.1
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Terminated [547784]
Company
Abbott Laboratories
Formula
C27H19F3N4O3
Canonical SMILES
c1([C@](COc2c(c3ccc(OC(F)(F)F)cc3)cc(C#N)cc2)(c2ccc(C#N<br />)cc2)O)n(cnc1)C.Cl
PubChem Compound ID
6451154
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [527723]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 547784Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019239)
Ref 527723Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9.

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