Drug Information

Drug General Information
Drug ID
D05WON
Former ID
DIB020920
Drug Name
SB-611812
Synonyms
SB611812
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540464]
Formula
C17H16Cl3F3N2O3S
InChI
InChI=1S/C17H16Cl3F3N2O3S/c1-25(2)5-6-28-15-9-11(3-4-12(15)18)24-29(26,27)16-13(19)7-10(8-14(16)20)17(21,22)23/h3-4,7-9,24H,5-6H2,1-2H3
InChIKey
UIZHOFJFIOCYLH-UHFFFAOYSA-N
PubChem Compound ID
10278166
PubChem Substance ID
15283185, 22655691, 35449371, 79688025, 103764854, 104142006, 137074987, 140166575, 172918561, 178100510, 223810832, 232255392, 241377115, 243526077, 249691251, 252158261
Target and Pathway
Target(s) Urotensin II receptor Target Info Antagonist [527752]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3531).
Ref 527752A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker. J Mol Cell Cardiol. 2005 Nov;39(5):785-91. Epub 2005 Sep 19.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.