Drug Information

Drug General Information
Drug ID
D05VEH
Drug Name
detirelix
Synonyms
102583-46-0; 89662-30-6; RS-68439; detirelix; detirelix acetate
Drug Type
Small molecular drug
Indication Unspecified Investigative [1559759], [1560044]
Formula
C78H105ClN18O13
PubChem Compound ID
70691429
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 1559759Gonadotropin-releasing hormone receptor-targeted paclitaxel-degarelix conjugate: synthesis and in vitro evaluation.J Pept Sci.2015 Jul;21(7):569-76.
Ref 1560044Inhibition of follicular development by a potent antagonistic analog of gonadotropin-releasing hormone (detirelix).

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