Drug Information

Drug General Information
Drug ID
D05UOW
Former ID
DNC000542
Drug Name
DFMO
Drug Type
Small molecular drug
Indication Discovery agent Withdrawn from market [545498]
Formula
C6H15ClF2N2O3
Canonical SMILES
C(CC(C(F)F)(C(=O)O)N)CN.O.Cl
InChI
1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChIKey
FJPAMFNRCFEGSD-UHFFFAOYSA-N
CAS Number
CAS 67037-37-0
PubChem Compound ID
441361
PubChem Substance ID
7847894, 10298810, 11528794, 12012626, 14847342, 26758603, 36885214, 57403653, 75862619, 85174277, 92721283, 103771020, 104625288, 118048823, 123392510, 125360341, 126619282, 131331440, 134339945, 135015827, 137045301, 162189306, 162228319, 163124492, 163688237, 176227366, 179685417, 204375137, 215781502, 223704632, 224835239, 225229710, 226396488, 241168103, 252348838
ChEBI ID
ChEBI:41948
SuperDrug ATC ID
P01CX03
SuperDrug CAS ID
cas=070052129
Target and Pathway
Target(s) Ornithine decarboxylase Target Info Inhibitor [534924]
BioCyc Pathway Putrescine biosynthesis I
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
References
Ref 545498Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003500)
Ref 534924X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. Biochemistry. 1999 Nov 16;38(46):15174-84.

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