Drug Information

Drug General Information
Drug ID
D05UHJ
Former ID
DIB016307
Drug Name
SM-10888
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 2 [544850]
Company
Sumitomo Pharmaceuticals Co Ltd
Formula
C54H55F3N6O14
Canonical SMILES
c12c(nc3c(c1N)c(F)ccc3)C1CC(C2)C1.C(CC(=O)O)(CC(=O)O)(C<br />(=O)O)O
CAS Number
CAS 116208-23-2
PubChem Compound ID
196829
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [532426]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 544850Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001320)
Ref 532426Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor. Jpn J Pharmacol. 1990 Jun;53(2):145-55.

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