Drug Information

Drug General Information
Drug ID
D05UDU
Former ID
DIB005870
Drug Name
YK-3237
Synonyms
Angiogenesis inhibitors (cancer); YK-3237; Angiogenesis inhibitors (cancer), Georgetown University
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543687]
Company
Georgetown University
Canonical SMILES
c1(c(c(cc(c1)C(=O)/C=C/c1ccc(c(c1)B(O)O)OC)OC)OC)OC
Target and Pathway
Target(s) NAD-dependent deacetylase sirtuin-1 Target Info Inhibitor [543687]
KEGG Pathway FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of Androgen receptor activity
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian Clock
WikiPathways Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathway
References
Ref 543687(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2707).
Ref 543687(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2707).

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