Drug Information

Drug General Information
Drug ID
D05QJT
Former ID
DNC014899
Drug Name
GW274150
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [521884]
Formula
C8H17N3O2S
Canonical SMILES
CC(=NCCSCCC(C(=O)O)N)N
InChI
1S/C8H17N3O2S/c1-6(9)11-3-5-14-4-2-7(10)8(12)13/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13)/t7-/m0/s1
InChIKey
MOLOJNHYNHBPCW-ZETCQYMHSA-N
PubChem Compound ID
9797017
PubChem Substance ID
14797918, 14797919, 24714761, 44833025, 57373353, 80949672, 103336660, 103985675, 128625089, 134223789, 141400277, 163642034, 198942494, 226492271
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Modulator [527488]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric Oxide
References
Ref 521884ClinicalTrials.gov (NCT00370435) Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA). U.S. National Institutes of Health.
Ref 527488Br J Pharmacol. 2005 Jun;145(3):301-12.GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.

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