Drug Information

Drug General Information
Drug ID
D05QCE
Former ID
DIB010705
Drug Name
KM-01221
Synonyms
Chymase inhibitors (cardiovascular disease); KM-01221; KM-06864; MWP-00965; TY-51076; Chymase inhibitors (cardiovascular disease), Toa Eiyo
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Investigative [543597]
Company
Toa Eiyo KK
Formula
C17H13Cl2N3O3S2
Canonical SMILES
S(=O)(=O)(c1sc2c(c1C)cc(cc2)F)Nc1c(S(=O)(=O)C)cc(C(=O)O<br />C)cc1
PubChem Compound ID
2819266
Target and Pathway
Target(s) Chymase Target Info Inhibitor [543597]
KEGG Pathway Renin-angiotensin system
Reactome Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 543597(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2340).
Ref 543597(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2340).

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