Drug Information

Drug General Information
Drug ID
D05OTZ
Former ID
DIB010599
Drug Name
SMP-986
Synonyms
Afacifenacin
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Phase 2 [548182]
Company
Sumitomo Pharmaceuticals Co Ltd
Canonical SMILES
C(F)(F)(Oc1cc(CN2CCC(N3[C@H](c4ccccc4NC3=O)c3ccccc3)CC2<br />)ccc1)F
Target and Pathway
Target(s) Sodium channel Target Info Antagonist [551635]
Muscarinic receptor Target Info Antagonist [551635]
KEGG Pathway Dopaminergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 548182Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022820)
Ref 551635DUAL INHIBITION OF Na+-CHANNEL AND MUSCARINIC RECEPTORS BY SMP-986 EFFICIENTLY IMPROVED VOIDING FUNCTION COMPARED TO ANTI-MUSCARINIC AGENTS IN TWO CONSCIOUS RAT MODELS OF DETRUSOR OVERACTIVITY. The Journal of Urology Volume 179, Issue 4, Supplement, April 2008, Pages 129.

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