Drug Information

Drug General Information
Drug ID
D05NTO
Former ID
DNC013419
Drug Name
6'-Iodononivamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531210]
Formula
C17H26INO3
Canonical SMILES
CCCCCCCCC(=O)NCC1=CC(=C(C=C1I)O)OC
InChI
1S/C17H26INO3/c1-3-4-5-6-7-8-9-17(21)19-12-13-10-16(22-2)15(20)11-14(13)18/h10-11,20H,3-9,12H2,1-2H3,(H,19,21)
InChIKey
AAORACFZMYMFCG-UHFFFAOYSA-N
PubChem Compound ID
5149140
Target and Pathway
Target(s) Vanilloid receptor Target Info Inhibitor [531210]
Vanilloid receptor 1 Target Info Inhibitor [531210]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 531210Bioorg Med Chem. 2010 Nov 15;18(22):8092-105. Epub 2010 Sep 18.Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.
Ref 531210Bioorg Med Chem. 2010 Nov 15;18(22):8092-105. Epub 2010 Sep 18.Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.

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