TTD | Drug: D05KNG

Drug General Information
Drug ID	D05KNG
Former ID	DIB011063
Drug Name	ALB-109564(a)
Synonyms	ALB-109564; Vinca alkaloid analogs (cancer), Albany Molecular Research
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[522388]
Company	Bessor-brightwaters pharma
Canonical SMILES	Cl.Cl.C(=O)([C@]1(c2c(c3c([nH]2)ccc(c3)SC)CCN2C[C@](C[C<br />@@H](C1)C2)(O)CC)c1cc2[C@@]34[C@H]([C@]([C@@H]([C@]5([C<br/>@@H]3N(CC4)CC=C5)CC)OC(=O)C)(C(=O)OC)O)N(c2cc1OC)C)OC
Target and Pathway
Target(s)	Tubulin beta	Target Info	Modulator
KEGG Pathway	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection
NetPath Pathway	FSH Signaling Pathway
	TCR Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Cytoskeletal regulation by Rho GTPase
PANTHER Pathway	Huntington disease
Reactome	Regulation of PLK1 Activity at G2/M Transition
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Anchoring of the basal body to the plasma membrane
WikiPathways	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection
	Mitotic G2-G2/M phases
References
Ref 522388	ClinicalTrials.gov (NCT00724100) A Trial of ALB 109564(a) in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health.

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Drug Information