Drug Information

Drug General Information
Drug ID
D05ICS
Former ID
DIB004891
Drug Name
ProSavin
Synonyms
Dopamine synthesis pathway gene therapy (Parkinson's disease), Oxford BioMedica
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 1/2 [524296]
Company
Oxford BioMedica plc
Target and Pathway
Target(s) GTP cyclohydrolase I Target Info Modulator [551478]
Aromatic-L-amino-acid decarboxylase Target Info Modulator [551478]
Tyrosine 3-monooxygenase Target Info Modulator [551478]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Serotonin and melatonin biosynthesis
Catecholamine biosynthesisPWY66-301:Catecholamine biosynthesis
KEGG Pathway Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00350:Tyrosine metabolism
Prolactin signaling pathway
Parkinson's disease
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine biosynthesis
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Nicotine pharmacodynamics pathway
Pathway Interaction Database ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Alpha-synuclein signaling
PathWhiz Pathway Pterine BiosynthesisPW000017:Catecholamine Biosynthesis
Tyrosine Metabolism
Tryptophan MetabolismPW000017:Catecholamine Biosynthesis
Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic NeuronsWP727:Monoamine Transport
Nicotine Activity on Dopaminergic Neurons
References
Ref 524296ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
Ref 551478Clinical pipeline report, company report or official report of Oxford BioMedica.

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