Drug Information

Drug General Information
Drug ID
D05HSI
Former ID
DIB001174
Drug Name
T-0632
Synonyms
Z-203; (S)-1-(2-Fluorophenyl)-3-(3-isoquinolinylcarboxamido)-6-methoxy-2-oxo-1H-indole-3-propionic acid sodium salt
Drug Type
Small molecular drug
Indication Pancreatic disease [ICD10:K85-K86] Discontinued in Phase 1 [543275], [546379]
Formula
C29H27FN2O5
InChI
InChI=1S/C29H27FN2O5/c1-37-21-12-13-22-25(17-21)32(24-9-5-4-8-23(24)30)28(36)29(22,15-14-26(33)34)31-27(35)20-11-10-18-6-2-3-7-19(18)16-20/h2-9,12-13,17,20H,10-11,14-16H2,1H3,(H,31,35)(H,33,34)/t20?,29-/m0/s1
InChIKey
RORYEMYJJAIHBK-PRTIIRGTSA-N
CAS Number
CAS 169042-78-8
PubChem Compound ID
127948
PubChem Substance ID
29307114, 76253977, 104367004, 135651222
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [534344]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 884).
Ref 546379Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007781)
Ref 534344Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis. Jpn J Pharmacol. 1997 Feb;73(2):105-12.

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