Drug Information

Drug General Information
Drug ID
D05HJG
Former ID
DNC010270
Drug Name
2,3-dihydro-1H-benzo[de]isoquinolin-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530584]
Formula
C12H9NO
Canonical SMILES
C1C2=CC=CC3=C2C(=CC=C3)C(=O)N1
InChI
1S/C12H9NO/c14-12-10-6-2-4-8-3-1-5-9(7-13-12)11(8)10/h1-6H,7H2,(H,13,14)
InChIKey
QGJHNXPHHOCUAH-UHFFFAOYSA-N
PubChem Compound ID
10130246
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [530584]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 530584Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Ref 530584Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

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