Drug Information

Drug General Information
Drug ID
D05GQK
Former ID
DIB020812
Drug Name
R-L3
Synonyms
R-L364,373
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539672]
Formula
C25H20FN3O
InChI
InChI=1S/C25H20FN3O/c1-29-23-13-7-4-10-19(23)24(18-9-2-5-11-20(18)26)28-22(25(29)30)14-16-15-27-21-12-6-3-8-17(16)21/h2-13,15,22,27H,14H2,1H3/t22-/m1/s1
InChIKey
CGBANSGENFERAT-JOCHJYFZSA-N
PubChem Compound ID
656755
PubChem Substance ID
854069, 9268123, 14854539, 14903448, 53787678, 80734304, 113528198, 127619985, 135650906, 136350359, 136936097, 163125162, 204370396, 223442220, 233127616, 241376058, 249617649, 252156692
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 1 Target Info Activator [534668]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathway
References
Ref 539672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2595).
Ref 534668A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Mol Pharmacol. 1998 Jul;54(1):220-30.

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