Drug Information

Drug General Information
Drug ID
D05FFR
Former ID
DNC000944
Drug Name
MGBG
Drug Type
Small molecular drug
Indication Head and neck cancer [ICD9: 140-149, 140-229; ICD10:C07-C14, C32-C33] Terminated [525957], [535793]
Formula
C5H12N8
Canonical SMILES
CC(=NN=C(N)N)C=NN=C(N)N
InChI
1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
InChIKey
MXWHMTNPTTVWDM-NXOFHUPFSA-N
CAS Number
CAS 13922-04-8
PubChem Compound ID
5351154
PubChem Substance ID
611216, 7888899, 12012645, 15195228, 39377781, 49974828, 51091596, 57361327, 77105216, 85301076, 103504484, 103977023, 113903809, 118049580, 124633349, 126591589, 126688706, 131315453, 132511295, 134340069, 134340223, 134340226, 134973137, 136352263, 137241210, 140630209, 164825287, 179225924, 179226390, 179685434, 223442568, 223670665, 226399648, 227917561, 237032998, 241088157, 249691017, 252559424, 252669978
SuperDrug ATC ID
L01XX16
SuperDrug CAS ID
cas=000459869
Target and Pathway
Target(s) S-adenosylmethioninedecarboxylase proenzyme Target Info Inhibitor [535032], [535955]
BioCyc Pathway Methionine salvage cycle III
Spermine biosynthesis
Spermidine biosynthesis
KEGG Pathway Cysteine and methionine metabolism
Arginine and proline metabolism
Metabolic pathways
NetPath Pathway EGFR1 Signaling Pathway
PathWhiz Pathway Spermidine and Spermine Biosynthesis
Methionine Metabolism
WikiPathways Metabolism of amino acids and derivatives
References
Ref 525957Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8.
Ref 535793S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
Ref 535032A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
Ref 535955New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity. Cancer Res. 1992 Sep 1;52(17):4712-8.

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