Drug Information

Drug General Information
Drug ID
D05ASV
Former ID
DIB006604
Drug Name
VTX-1463
Synonyms
TLR-8 agonist (allergic rhinitis), VentiRx
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Phase 1 [548896]
Company
VentiRx Pharmaceuticals Inc
Target and Pathway
Target(s) Toll-like receptor 8 Target Info Agonist [531464]
KEGG Pathway Toll-like receptor signaling pathway
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 548896Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030038)
Ref 531464VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6.

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