Drug Information

Drug General Information
Drug ID
D04ZND
Former ID
DIB009471
Drug Name
PGL-2001
Synonyms
Steroid sulfatase inhibitor (endometriosis), PregLem
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 2 [523963]
Company
Ipsen
Target and Pathway
Target(s) Steryl-sulfatase Target Info Inhibitor [532697]
KEGG Pathway Steroid hormone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Glycosphingolipid metabolism
WikiPathways Estrogen metabolism
Vitamin D Receptor Pathway
Sphingolipid metabolism
References
Ref 523963ClinicalTrials.gov (NCT01631981) PGL2001 Proof of Concept Study in Symptomatic Endometriosis. U.S. National Institutes of Health.
Ref 532697Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65.

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