Drug Information

Drug General Information
Drug ID
D04VTV
Former ID
DIB001199
Drug Name
SYN-114
Synonyms
5-HT 6 receptor antagonists (cognitive disorders), Synosia/Roche
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 1 [548444]
Company
Roche Holding AG
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [544005]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548444Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025583)
Ref 544005Lewy bodies. Proc Natl Acad Sci U S A. 2006 February 7; 103(6): 1661-1668.

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