Drug Information

Drug General Information
Drug ID
D04UBY
Former ID
DNC009967
Drug Name
5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530333]
Formula
C18H17NO3
Canonical SMILES
C1=CC(=CC(=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O)C#N
InChI
1S/C18H17NO3/c19-12-14-2-1-3-16(10-14)15-7-4-13(5-8-15)6-9-17(20)11-18(21)22/h1-5,7-8,10,17,20H,6,9,11H2,(H,21,22)
InChIKey
WILNYVYWCSPWAP-UHFFFAOYSA-N
PubChem Compound ID
45483018
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [530333]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

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