Drug Information

Drug General Information
Drug ID
D04TNT
Former ID
DNCL002937
Drug Name
ABT-639
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 2 [533259], [542694]
Formula
C20H20ClF2N3O3S
InChIKey
AGPIHNZOZNKRGT-CYBMUJFWSA-N
PubChem Compound ID
46851313
PubChem Substance ID
99240370, 120890113, 223366054, 224413548, 226728676, 247990000
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Modulator [533259]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 533259Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. Pain. 2015 Nov;156(11):2175-83.
Ref 542694(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7721).
Ref 533259Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. Pain. 2015 Nov;156(11):2175-83.

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