Drug Information

Drug General Information
Drug ID
D04SCQ
Former ID
DNC010216
Drug Name
4,4-Diphenylbutan-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530331]
Formula
C16H19N
Canonical SMILES
C1=CC=C(C=C1)C(CCCN)C2=CC=CC=C2
InChI
1S/C16H19N/c17-13-7-12-16(14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16H,7,12-13,17H2
InChIKey
MAAQGZFMFXQVOG-UHFFFAOYSA-N
PubChem Compound ID
3015863
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530331]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [530331]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

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