Drug Information

Drug General Information
Drug ID
D04RUP
Former ID
DIB001543
Drug Name
SDZ-NKT-343
Synonyms
NKT-343; SDZ-250343
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 1 [546834]
Company
Novartis AG
Formula
C33H33N5O5
Canonical SMILES
C(=O)(N1[C@H](C(=O)N[C@H](C(=O)N(Cc2ccccc2)C)Cc2cc3c(cc<br />2)cccc3)CCC1)Nc1c([N+](=O)[O-])cccc1
CAS Number
CAS 180046-99-5
PubChem Compound ID
9851211
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [534708]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546834Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010524)
Ref 534708The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Exp Brain Res. 1998 Aug;121(3):355-8.

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