Drug Information

Drug General Information
Drug ID
D04PMM
Former ID
DCL000455
Drug Name
AZD1386
Drug Type
Small molecular drug
Indication Esophagus sensitivity; Gastroesophageal reflux disease [ICD9: 530, 140-229; ICD10:K20-K22, K21] Discontinued in Phase 2 [542765], [548687]
Therapeutic Class
Analgesics
Company
AstraZeneca
Formula
C19H13ClF3N3O3
InChI
InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)
InChIKey
DXDVSYALLVVBOV-UHFFFAOYSA-N
PubChem Compound ID
24752296
PubChem Substance ID
49654639, 56167349, 196372375, 223366151, 230204131, 244172784
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [550288]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 542765(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7820).
Ref 548687Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027672)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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