Drug Information

Drug General Information
Drug ID
D04PKP
Former ID
DNC006004
Drug Name
3-(1,2-dihydroacenaphthylen-5-yl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527819]
Formula
C17H13N
Canonical SMILES
C1CC2=CC=CC3=C(C=CC1=C23)C4=CN=CC=C4
InChI
1S/C17H13N/c1-3-12-6-7-13-8-9-15(16(5-1)17(12)13)14-4-2-10-18-11-14/h1-5,8-11H,6-7H2
InChIKey
BWVFIMXEVGYZOM-UHFFFAOYSA-N
PubChem Compound ID
23644953
Target and Pathway
Target(s) Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [527819]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Corticotropin-releasing hormone
References
Ref 527819Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30. Epub 2005 Oct 21.Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).
Ref 527819Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30. Epub 2005 Oct 21.Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).

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