TTD | Drug: D04NAL

Drug General Information
Drug ID	D04NAL
Former ID	DIB020276
Drug Name	LY314228
Synonyms	LY 314228; LY-314228
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539135]
Formula	C20H24N4O3
InChI	InChI=1S/C20H24N4O3/c1-3-4-18-15(7-10-17(13(2)25)19(18)26)12-27-16-8-5-14(6-9-16)11-23-24-20(21)22/h5-11,26H,3-4,12H2,1-2H3,(H4,21,22,24)/b23-11+
InChIKey	TUXHQPAMNGTVLT-FOKLQQMPSA-N
PubChem Compound ID	9976312
PubChem Substance ID	14954102, 44027652, 48029719, 48254029, 78256778, 136351102
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Antagonist	[534232]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 539135	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 181).
Ref 534232	A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68.

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Drug Information