Drug Information

Drug General Information
Drug ID
D04LLU
Former ID
DIB018137
Drug Name
[125I](-)ICYP
Synonyms
(-)[125I]iodocyanopindolol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540806]
Formula
C15H18IN3O2
InChI
InChI=1S/C15H18IN3O2/c1-9(2)18-7-10(20)8-21-13-5-3-4-11-14(13)15(16)12(6-17)19-11/h3-5,9-10,18-20H,7-8H2,1-2H3/i16-2
InChIKey
WGSPBWSPJOBKNT-RFLHHMENSA-N
PubChem Compound ID
68618
PubChem Substance ID
29162495, 43125165, 50065284, 57316968, 78944988, 81065554, 85209117, 103100497, 104342625, 117512294, 126423918, 135026274, 162919091, 223365918
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [527007]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540806(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 540).
Ref 527007Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors. Br J Pharmacol. 2004May;142(1):51-6. Epub 2004 Mar 22.

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