Drug Information

Drug General Information
Drug ID
D04KCX
Former ID
DNC014391
Drug Name
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530900]
Formula
C8H6N2O2S
Canonical SMILES
C1=CC(=O)C=CC1=C2NNC(=S)O2
InChI
1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,9H,(H,10,13)
InChIKey
SUVWGKRXUGXUMP-UHFFFAOYSA-N
PubChem Compound ID
5385959
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [530900]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

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