Drug Information

Drug General Information
Drug ID
D04JMI
Former ID
DIB000973
Drug Name
Plasma derived human butyrylcholinesterase
Synonyms
Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity); HuBChE (im, drug induced neurotoxicity), Dynport; Bioscavenger (im, drug induced neurotoxicity), Dynport/Baxter; Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity), Dynport/Baxter
Indication Neurotoxicity drug-induced [ICD10:T36-T50] Phase 1 [521839]
Company
DynPort Vaccine Company LLC
Target and Pathway
Target(s) Cholinesterase Target Info Modulator [533276]
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
WikiPathways Irinotecan Pathway
References
Ref 521839ClinicalTrials.gov (NCT00333528) A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly. U.S. National Institutes of Health.
Ref 533276Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8.

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