TTD | Drug: D04IWB

Drug General Information
Drug ID	D04IWB
Former ID	DIB018578
Drug Name	2-thioUTP
Synonyms	2-thio-UTP
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540344]
Formula	C9H15N2O14P3S
InChI	InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
InChIKey	KHYOUGAATNYCAZ-XVFCMESISA-N
PubChem Compound ID	10174453
PubChem Substance ID	15168526, 22570653, 40158602, 77183207, 103502085, 104079840, 128384971, 178100411, 226925309
Target and Pathway
Target(s)	P2Y purinoceptor 2	Target Info	Agonist	[528542]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL5 Signaling Pathway
Reactome	G alpha (q) signalling events
	P2Y receptors
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540344	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3398).
Ref 528542	Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87.

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Drug Information