Drug Information

Drug General Information
Drug ID
D04IJB
Former ID
DIB018167
Drug Name
[125I]resiniferatoxin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539617]
Formula
C37H39IO9
InChI
InChI=1S/C37H39IO9/c1-20(2)35-16-22(4)37-26(33(35)45-36(46-35,47-37)18-23-9-7-6-8-10-23)12-25(17-34(42)29(37)11-21(3)32(34)41)19-44-30(39)15-24-13-27(38)31(40)28(14-24)43-5/h6-14,22,26,29,33,40,42H,1,15-19H2,2-5H3/t22-,26+,29-,33-,34-,35-,36-,37-/m1/s1/i38-2
InChIKey
TZUJORCXGLGWDV-FOFZJNPASA-N
PubChem Compound ID
73755027
PubChem Substance ID
135652719
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker (channel blocker) [525935]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 539617(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2492).
Ref 525935Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol Pharmacol. 2001 Jan;59(1):9-15.

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