Drug Information

Drug General Information
Drug ID
D04GRB
Former ID
DIB001435
Drug Name
THRX-198321
Synonyms
Beta 2 adrenoreceptor agonist/muscarinic receptor antagonist (asthma), Theravance
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Phase 2 [549872]
Company
GlaxoSmithKline; Theravance
Canonical SMILES
c1cc(ccc1)c1ccccc1NC(=O)OC1CCN(CC1)CCCCCCCCCNC[C@H](O)c<br />1ccc(c2c1ccc(=O)[nH]2)O
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Modulator [531285]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 549872Clinical pipeline report, company report or official report of Theravance.
Ref 531285THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol. 2011 Mar;79(3):389-99.

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