Drug Information

Drug General Information
Drug ID
D04GHG
Former ID
DIB000011
Drug Name
Pim1 inhibitors
Synonyms
Pim1 inhibitors (cancer); Pim1 inhibitors (cancer), CNIO
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552164]
Company
Centro Nacional de Investigaciones Oncologicas
Canonical SMILES
c1(c(nn2c(c1)ncc2C(=O)Nc1ccccc1)NCc1ccc(cc1)OC)C
Target and Pathway
Target(s) Proto-oncogene pim-1 Target Info Inhibitor [543563]
KEGG Pathway Jak-STAT signaling pathway
MicroRNAs in cancer
Acute myeloid leukemia
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 552164WO patent application no. 2004058769, COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES.
Ref 543563(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).

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