Drug Information

Drug General Information
Drug ID
D04EPO
Former ID
DNC009540
Drug Name
7-Hydroxy-3-(3-hydroxyphenyl)-1-naphthonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529595]
Formula
C17H11NO2
Canonical SMILES
C1=CC(=CC(=C1)O)C2=CC3=C(C=C(C=C3)O)C(=C2)C#N
InChI
1S/C17H11NO2/c18-10-14-7-13(11-2-1-3-15(19)8-11)6-12-4-5-16(20)9-17(12)14/h1-9,19-20H
InChIKey
UXJULIKCAFGFJL-UHFFFAOYSA-N
PubChem Compound ID
24950551
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [529595]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 529595J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
Ref 529595J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.

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