Drug Information

Drug General Information
Drug ID
D04DKL
Former ID
DNCL002568
Drug Name
ALT-836
Indication Adult respiratory distress syndrome [ICD9: 518.5, 518.82; ICD10:J80] Phase 2 [522632]
Company
Altor BioScience
Target and Pathway
Target(s) Tissue factor Target Info Inhibitor [533187]
KEGG Pathway Complement and coagulation cascades
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TWEAK Signaling Pathway
PANTHER Pathway Angiogenesis
Blood coagulation
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
WikiPathways Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 522632ClinicalTrials.gov (NCT00879606) Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome. U.S. National Institutes of Health.
Ref 533187ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1295-303.

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