Drug Information

Drug General Information
Drug ID
D04BLE
Former ID
DIB002541
Drug Name
A-3309
Synonyms
Elobixibat; ALBI-3309; AZD-7806; AZD-7806); Ileal bile acid transporter inhibitors, AstraZeneca; ASBT inhibitor (oral, chronic idiopathic constipation), Albireo; IBAT inhibitor (oral, chronic idiopathic constipation), Albireo; Apical sodium-dependent bile acid transporter inhibitor (oral, chronic idiopathic constipation), Albireo; IBAT inhibitors (1,5-benzothiazepine derivatives), AstraZeneca
Indication Lipid metabolism disorder [ICD10:E75-E78] Phase 3 [524353]
Company
AstraZeneca plc
Canonical SMILES
c12N(CC(CS(=O)(=O)c1cc(c(c2)SC)OCC(=O)N[C@H](c1ccccc1)C<br />(=O)NCC(=O)O)(CCCC)CCCC)c1ccccc1
CAS Number
CAS 439087-18-0
Target and Pathway
Target(s) Ileal bile acid transfer Target Info Inhibitor [532143]
KEGG Pathway Bile secretion
Reactome Recycling of bile acids and salts
WikiPathways Bile acid and bile salt metabolism
References
Ref 524353ClinicalTrials.gov (NCT01895543) Safety and Tolerability Extension Trial for Patients With Chronic Idiopathic Constipation. U.S. National Institutes of Health.
Ref 532143Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.

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