Drug Information

Drug General Information
Drug ID
D03QQH
Former ID
DIB019771
Drug Name
AMA37
Synonyms
AMA37; arylmorpholine analog 37
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541241]
Formula
C17H17NO3
InChI
InChI=1S/C17H17NO3/c19-16-12-14(18-8-10-21-11-9-18)6-7-15(16)17(20)13-4-2-1-3-5-13/h1-7,12,19H,8-11H2
InChIKey
FALILNHGILFDLC-UHFFFAOYSA-N
PubChem Compound ID
16760391
PubChem Substance ID
26758569, 46580842, 47573647, 53800933, 57381768, 85845675, 99302837, 103639292, 104115414, 137013884, 139537280, 163125938, 163688270, 175607401, 178102584, 179042909, 204375286, 208265140, 223784955, 229247692, 248028884
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [528888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 541241(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5961).
Ref 528888Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. Epub 2007 Jun 11.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.