Drug Information

Drug General Information
Drug ID
D03KQG
Former ID
DNC012069
Drug Name
Pyrrolidin-1-yl-thiourea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527001]
Formula
C5H11N3S
Canonical SMILES
C1CCN(C1)NC(=S)N
InChI
1S/C5H11N3S/c6-5(9)7-8-3-1-2-4-8/h1-4H2,(H3,6,7,9)
InChIKey
LUZJFNYVKQEEGM-UHFFFAOYSA-N
PubChem Compound ID
44291858
Target and Pathway
Target(s) Vanilloid receptor Target Info Inhibitor [527001]
Vanilloid receptor 1 Target Info Inhibitor [527001]
Transient receptor potential cation channel subfamily V member 4 Target Info Inhibitor [527001]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channelsR-HSA-3295583:TRP channels
References
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

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